05/18/2023
On JCI's : Altered gut microbiome in multiple sclerosis: https://buff.ly/3NfsCEM
Ma, Sannino, and Linden et al. report that Clostridium perfringens producing epsilon toxin occur in high abundance within the gut microbiome in people with multiple sclerosis and that epsilon toxin is sufficient to induce inflammatory demyelination in susceptible mice.
The cover image is an artist’s rendering of ETX-producing Clostridium perfringens in the small intestines and the contribution of epsilon toxin pores in the inflammatory response that results in damage to myelin sheaths.
Image credit: 2023 Audra Geras Biomedical Art/Geras Healthcare Productions.
